I enjoyed Oblivion, but was told by others that Morrowind was the superior game, so I bought that and couldn't get past how visually unattractive it was. Sure, it had a very, very large map but it was largely lifeless, the character movement was stilted and static, looked unnatural to me- not to mention the character modeling. This is what happens though, when you go to play a game that is already several years old and built for a more-or-less obsolete system. I couldn't appreciate any of it. When I got to Skyrim, same thing happened w/Oblivion, but it wasn't as dramatic.
Just to test that theory, I popped in my old GTA: San Andreas and found it equally as horrible visually...as much as I liked that game the differences between it and current-gen systems was glaringly obvious.
Personally, I'd like to see a game come out that falls directly in that Uncanny Valley that seems to put so many people off; I wonder how it would feel to kill an enemy that looked like a living, breathing human, not just a stylized version of one. I'm still making my way through GTA V and it is the closest to realistic people that I've seen in a game of that magnitude...of course, having never played ME, they might trump it. At least screenshots seem to bear that out.